Gilead’s Captisol-enabled Remdesivir Approved for Use in Renally Impaired Patients
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Case Studies

Poorly Soluble Compounds

"Currently, between 70 and 90% of drug candidates in pipelines are believed to have low solubility. In fact, poor solubility problems is considered to be the leading challenge in drug development"
- Chemical Engineering News 2010

Captisol® Solutions

Captisol® enables the creation of new products by significantly improving solubility, stability, bioavailability, safety and dosing of active pharmaceutical ingredients (APIs). 

Captisol® is a circular-shaped molecule with a hydrophilic exterior surface and hydrophilic interior cavity. The hydrophilic surface generates good water solubility and a relatively hydrophobic interior cavity provides a favorable environment for water insoluble drug molecules.